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Non-genotoxic transplantation and in vivo selection through epitope editing

Gabriele Casirati

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10737-8

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle cell disease and β-thalassemia. Read More Nature

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